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Brief Communication

Nature Genetics 40, 152–154 (1 February 2008) | doi:10.1038/ng.71

A nonsynonymous functional variant in integrin-|[alpha]|M (encoded by ITGAM) is associated with systemic lupus erythematosus

Swapan K Nath , Shizhong Han , Xana Kim-Howard , Jennifer A Kelly , Parvathi Viswanathan , Gary S Gilkeson , Wei Chen , Cheng Zhu , Rodger P McEver , Robert P Kimberly , Marta E Alarc|[oacute]|n-Riquelme , Timothy J Vyse , Quan-Zhen Li , Edward K Wakeland , Joan T Merrill , Judith A James , Kenneth M Kaufman , Joel M Guthridge & John B Harley

We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 |[times]| 10|[minus]|17, odds ratio = 1.78).