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Letter

Nature Genetics 40, 225–231 (1 February 2008) | doi:10.1038/ng.2007.57

Genome-wide analysis of transcript isoform variation in humans

Tony Kwan , David Benovoy , Christel Dias , Scott Gurd , Cathy Provencher , Patrick Beaulieu , Thomas J Hudson , Rob Sladek & Jacek Majewski

We have performed a genome-wide analysis of common genetic variation controlling differential expression of transcript isoforms in the CEU HapMap population using a comprehensive exon tiling microarray covering 17,897 genes. We detected 324 genes with significant associations between flanking SNPs and transcript levels.