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Nature Genetics 40, 134 - 135 (2008)
doi:10.1038/ng0208-134
Two ways to make an mtDNA bottleneck
Konstantin Khrapko1
- Konstantin Khrapko is at Beth Israel Deaconess Medical Center and Harvard Medical School, 21-27 Burlington Avenue, Boston, Massachusetts 02215, USA. e-mail: khrapko@hms.harvard.edu
Abstract
Rapid changes in mitochondrial DNA allele frequency between generations have been explained by an 'mtDNA bottleneck' in the germ line, and it has recently been proposed that mtDNA aggregates, or nucleoids, drive such a bottleneck. Now, a new study finds a sharp reduction in mtDNA content in the germ line and suggests that such reduction alone may account for the bottleneck effect.
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RESEARCH
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypesNature Genetics Letter (01 Feb 2008)
The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomesNature Genetics Letter (01 Dec 2008)
The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cellsNature Genetics Letter (01 Mar 2007)
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