News and Views

Nature Genetics 40, 131 - 132 (2008)

The developing mosaic of autoimmune disease risk

Lisa M Maier1 & David A Hafler1

  1. Lisa M. Maier and David A. Hafler are in the Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Ave. Louis Pasteur NRB 641, Boston, MA 02115 and at the Broad Institute of Harvard University and Massachusetts Institute of Technology. e-mail:

The discovery of new risk variants for systemic lupus erythematosis (SLE), particularly around lymphocyte signaling pathways and integrins involved in clearing complement, provides fresh insights into this common human autoimmune disease. Understanding the role of the variants in disease pathophysiology and translating these findings into new therapies present major and urgent challenges to medical scientists.