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Nature Genetics 40, 1394–1395 (1 December 2008) | doi:10.1038/ng1208-1394

Nonsynonymous variants and fatty liver disease

Karen L Mohlke

Nonalcoholic fatty liver disease (NAFLD) is characterized by excess fat in the liver of people who drink little or no alcohol and have no viral or autoimmune liver disease. Fat, mainly triacylglycerol, accumulates in the liver cells, as observed histologically (Fig.