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Letter
Nature Genetics 40, 1478–1483 (1 December 2008) | doi:10.1038/ng.250
Embryonic stem cell|[ndash]|specific microRNAs regulate the G1-S transition and promote rapid proliferation
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Abstract
Dgcr8 knockout embryonic stem (ES) cells lack microprocessor activity and hence all canonical microRNAs (miRNAs). These cells proliferate slowly and accumulate in G1 phase of the cell cycle.
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