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Nature Genetics 40, 1394 - 1395 (2008)
doi:10.1038/ng1208-1394
Nonsynonymous variants and fatty liver disease
Karen L Mohlke1
- Karen L. Mohlke is in the Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA. e-mail: mohlke@med.unc.edu
Abstract
Fat accumulation in the liver is a common trait that may progress to severe liver disease. A new study identifies common and rare nonsynonymous variants in PNPLA3 that are associated with hepatic triglyceride content and that may explain some of the population differences in prevalence.
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