Brief Communication abstract

Nature Genetics 40, 1404 - 1406 (2008)
Published online: 2 November 2008 | doi:10.1038/ng.254

Lung cancer susceptibility locus at 5p15.33

James D McKay1,25, Rayjean J Hung1,2,25, Valerie Gaborieau1,25, Paolo Boffetta1, Amelie Chabrier1, Graham Byrnes1, David Zaridze3, Anush Mukeria3, Neonilia Szeszenia-Dabrowska4, Jolanta Lissowska5, Peter Rudnai6, Eleonora Fabianova7, Dana Mates8, Vladimir Bencko9, Lenka Foretova10, Vladimir Janout11, John McLaughlin2,12, Frances Shepherd13, Alexandre Montpetit14, Steven Narod15, Hans E Krokan16, Frank Skorpen16, Maiken Bratt Elvestad16, Lars Vatten16, Inger Njølstad17, Tomas Axelsson18, Chu Chen19, Gary Goodman19, Matt Barnett19, Melissa M Loomis19, Jan Lubiñski1, Joanna Matyjasik20, Marcin Lener20, Dorota Oszutowska20, John Field21, Triantafillos Liloglou21, George Xinarianos21, Adrian Cassidy21, EPIC Study24, Diana Zelenika22, Anne Boland22, Marc Delepine22, Mario Foglio22, Doris Lechner22, Fumihiko Matsuda22, Helene Blanche23, Ivo Gut22, Simon Heath22, Mark Lathrop22,23 & Paul Brennan1

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We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 times 10-7 and P = 4 times 10-6) and replicated by the independent study series (P = 7 times 10-5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

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  1. International Agency for Research on Cancer (IARC), Lyon 69008, France.
  2. Samuel Lunenfeld Research Institute, Toronto M5T 3L9, Canada.
  3. Institute of Carcinogenesis, Cancer Research Centre, Moscow 115478, Russia.
  4. Department of Epidemiology, Institute of Occupational Medicine, Lodz 90950, Poland.
  5. The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02781, Poland.
  6. National Institute of Environmental Health, Budapest 1097, Hungary.
  7. Specialized Institute of Hygiene and Epidemiology, Banska Bystrica 97556, Slovakia.
  8. Institute of Public Health, Bucharest 050463, Romania.
  9. Charles University in Prague, First Faculty of Medicine, Institute of Hygiene and Epidemiology, Prague 2 12800, Czech Republic.
  10. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno 65653, Czech Republic.
  11. Palacky University, Olomouc 77515, Czech Republic.
  12. Cancer Care Ontario, Toronto M5G 2L7, Canada.
  13. Princess Margaret Hospital, Ontario Cancer Institute, Toronto M5G 2M9, Canada.
  14. McGill University and Genome Quebec Innovation Centre, Montreal H3A 1A4, Canada.
  15. Women's College Research Institute, Toronto M5G 1N8, Canada.
  16. Norwegian University of Science and Technology, Trondheim 7489, Norway.
  17. Institute of Community Medicine, University of Tromsø, Tromsø 9037, Norway.
  18. Uppsala University, Department of Medical Sciences, SNP Technology Platform, Academic Hospital, Uppsala 751 85, Sweden.
  19. Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  20. Pomeranian Medical University, Department of Genetics and Pathology, International Hereditary Cancer Center, Szczecin 70 115, Poland.
  21. Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool L3 9TA, UK.
  22. Commissariat à l'énergie Atomique, Institut Genomique, Centre National de Genotypage, Evry 91000, France.
  23. Fondation Jean Dausset-CEPH, Paris 75010, France.
  24. A full list of authors appears at the end of this paper.
  25. These authors contributed equally to this work.
  26. Servizio di Epidemiologia dei Tumori, Università di Torino and CPO-Piemonte, Turin 10126, Italy.
  27. Department of Epidemiology and Public Health, Imperial College, London SW7, UK.
  28. INSERM, E3N-EPIC Group Institut Gustave Roussy, Villejuif 94805, France.
  29. Molecular and Nutrional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence 50139, Italy.
  30. Cancer Registry and Histopathology Unit, Azienda Ospedaliera "Civile M.P. Arezzo," Ragusa 97100, Italy.
  31. Istituto Nazionale dei Tumori, Milan 20133, Italy.
  32. Dipartimento di Medicina Clinica e Sperimentale, Universita di Napoli, Federico II, Naples 80131, Italy.
  33. Servicio de Epidemiología y registro del Cáncer, Instituto Catalán de Oncología, Barcelona 08907, Spain.
  34. Jefe Sección Información Sanitaria, Consejería de Servicios Sociales, Principado de Asturias, Oviedo 33001, Spain.
  35. Escuela Andaluza de Salud Pública, Granada 18011, Spain.
  36. Epidemiology Department, Murcia Health Council, Murcia 18011, Spain.
  37. CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona 8003, Spain.
  38. Registro de Cáncer de Navarra, Instituto de Salud Pública, Gobierno de Navarra, Pamplona 31003, Spain.
  39. Subdirección de Salud Pública de Gipuzkoa, Gobierno Vasco, San Sebastian 20113, Spain.
  40. MRC Dunn Human Nutrition Unit, Cambridge CB2 0XY, UK.
  41. Cancer Research UK, University of Oxford, Oxford 0X3 7XP, UK.
  42. Centre for Food and Health, National Institute of Public Health and the Environment (RIVM), Bilthoven 3720 BA, The Netherlands.
  43. Julius Center for Health Sciences and Primary Care, Department of Epidemiology, University of Utrecht, Utrecht 3508 GA, The Netherlands.
  44. Department of Hygiene and Epidemiology, University of Athens, Athens 11527, Greece.
  45. Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg 69120, Germany.
  46. Department of Epidemiology, Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke 14558, Germany.
  47. Department of Public Health and Clinical Medicine, University of Umeå, Umeå 90187, Sweden.
  48. Department of Epidemiology and Social Medicine, Aarhus University, Aarhus 8000, Denmark.
  49. The Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen 2100, Denmark.
  50. Institute of Community Medicine, University of Tromsø, Tromsø 9037, Norway.

Correspondence to: Paul Brennan1 e-mail: brennan@iarc.fr



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