Brief Communication abstract
Nature Genetics 40, 1399 - 1401 (2008)
Published online: 2 November 2008 | doi:10.1038/ng.249
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
Jason D Cooper1, Deborah J Smyth1, Adam M Smiles2, Vincent Plagnol1, Neil M Walker1, James E Allen1, Kate Downes1, Jeffrey C Barrett1, Barry C Healy1, Josyf C Mychaleckyj3, James H Warram2 & John A Todd1
Abstract
We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 
10-8) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 10-12), 10p15 (PRKCQ, P = 3.7 10-9), 15q24 (CTSH, P = 3.2 10-15) and 22q13 (C1QTNF6, P = 2.0 10-8).
- Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0XY, UK.
- Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA.
- Center for Public Health Genomics, University of Virginia, Virginia 22908, USA.
Correspondence to: Jason D Cooper1 e-mail: jason.cooper@cimr.cam.ac.uk
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