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Rapidly evolving human promoter regions

Nature Genetics volume 40, pages 1262–1263 (2008)Cite this article

To the Editor:

There is a great deal of interest in discovering the genetic changes that differentiate humans from other species, in particular our closest relatives, the great apes. It has long been anticipated1 that many of the genetic differences between these species may be largely attributable to changes in the regulation of genes rather than differences in gene complement or function.

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Figure 1: Comparison of substitution rate between promoter and paired, local intronic alignments.

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Acknowledgements

M.S.T. and N.G. are supported by Wellcome Trust Program Grant GR078968. C.A.M.S. is supported by the UK Medical Research Council.

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Authors and Affiliations

  1. European Molecular Biology Laboratory European Bioinformatics Institute, Hinxton, CB10 1SD, Cambridge, UK

    Martin S Taylor, Tim Massingham & Nick Goldman

  2. RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Kanagawa, Japan

    Yoshihide Hayashizaki

  3. Genome Science Laboratory, Discovery and Research Institute, RIKEN Wako Institute, 2-1 Hirosawa, Wako, 351-0198, Saitama, Japan

    Piero Carninci

  4. Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK

    Colin A M Semple

Authors
  1. Martin S Taylor
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  2. Tim Massingham
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  3. Yoshihide Hayashizaki
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  4. Piero Carninci
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  5. Nick Goldman
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  6. Colin A M Semple
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Corresponding author

Correspondence to Martin S Taylor.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Note and Supplementary Figure 1 (PDF 120 kb)

Supplementary Table 1

Branch-length estimates and P values (XLS 1489 kb)

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Taylor, M., Massingham, T., Hayashizaki, Y. et al. Rapidly evolving human promoter regions. Nat Genet 40, 1262–1263 (2008). https://doi.org/10.1038/ng1108-1262

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