Brief Communication abstract


Nature Genetics 40, 1279 - 1281 (2008)
Published online: 12 October 2008 | doi:10.1038/ng.228

Susceptibility variants for male-pattern baldness on chromosome 20p11

Axel M Hillmer1,9, Felix F Brockschmidt1,9, Sandra Hanneken2, Sibylle Eigelshoven2, Michael Steffens3, Antonia Flaquer3, Stefan Herms1, Tim Becker3, Anne-Katrin Kortüm2, Dale R Nyholt4, Zhen Zhen Zhao4, Grant W Montgomery4, Nicholas G Martin4, Thomas W Mühleisen1, Margrieta A Alblas1, Susanne Moebus5, Karl-Heinz Jöckel5, Martina Bröcker-Preuss6, Raimund Erbel7, Roman Reinartz1, Regina C Betz8, Sven Cichon1,8, Peter Propping8, Max P Baur3, Thomas F Wienker3, Roland Kruse2 & Markus M Nöthen1,8

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We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 times 10-15). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.

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  1. Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.
  2. Department of Dermatology, University of Düsseldorf, D-40225 Düsseldorf, Germany.
  3. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, D-53105 Bonn, Germany.
  4. Genetic Epidemiology, Queensland Institute of Medical Research, QLD 4006 Brisbane, Australia.
  5. Institute for Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, D-45122 Essen, Germany.
  6. Clinic of Endocrinology, Central Laboratory Unit Research and Education, University Hospital of Essen, University Duisburg-Essen, D-45122 Essen, Germany.
  7. Clinic of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, D-45122 Essen, Germany.
  8. Institute of Human Genetics, University of Bonn, D-53111 Bonn, Germany.
  9. These authors contributed equally to this work.

Correspondence to: Axel M Hillmer1,9 e-mail: axel.hillmer@uni-bonn.de



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