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Letter
Nature Genetics 40, 1240–1244 (1 October 2008) | doi:10.1038/ng.211
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
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Abstract
Kras is the most frequently mutated ras family member in lung carcinomas, whereas Hras mutations are common in tumors from stratified epithelia such as the skin. Using a Hras knock-in mouse model, we demonstrate that specificity for Kras mutations in lung and Hras mutations in skin tumors is determined by local regulatory elements in the target ras genes.
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