News and Views
Nature Genetics 40, 1149 - 1150 (2008)
doi:10.1038/ng1008-1149
Kras and Hras—what is the difference?
Anton Berns1
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Anton Berns is at the Division of Molecular Genetics, Centre for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.
e-mail: a.berns@nki.nl
Abstract
Kras, Hras or Nras mutations occur at varying frequencies across different tumors in humans for unknown reasons. A new study shows that, in mice, locus-specific regulatory elements determine whether mutations in Hras or Kras will predominate in lung and skin tumors.
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