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Nature Genetics 40, 1145 - 1146 (2008)
doi:10.1038/ng1008-1145
Kidney disease and African ancestry
Martin R Pollak1
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Martin R. Pollak is in the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
e-mail: mpollak@rics.bwh.harvard.edu
Abstract
Mapping by admixture linkage disequilibrium (MALD) leverages differences in disease frequencies among ancestry groups to map disease-susceptibility loci on the basis of genetic admixture. Two new studies use MALD to identify variation at the MYH9 locus as a major factor for the increased risk of nondiabetic kidney disease in African Americans.
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