Brief Communication abstract
Nature Genetics 40, 1156 - 1159 (2008)
Published online: 14 September 2008 | doi:10.1038/ng.218
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Anne Barton1, Wendy Thomson1, Xiayi Ke1, Steve Eyre1, Anne Hinks1, John Bowes1, Darren Plant1, Laura J Gibbons1, Wellcome Trust Case Control Consortium7, YEAR Consortium7, BIRAC Consortium7, Anthony G Wilson2, Deborah E Bax2, Ann W Morgan3, Paul Emery3, Sophia Steer4, Lynne Hocking5, David M Reid5, Paul Wordsworth6, Pille Harrison6 & Jane Worthington1
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 
10-4 - 1 10-5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 10-5, P = 4 10-4 and P = 4 10-4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
- Arthritis Research Campaign (arc) Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK.
- School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK.
- Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds LS7 4SA, UK.
- Clinical and Academic Rheumatology, Kings College Hospital National Health Service Foundation Trust, Denmark Hill, London SE5 9RS, UK.
- Bone Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK.
- University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford OX3 7LD, UK.
- A full list of members is provided in the Supplementary Note online.
Correspondence to: Anne Barton1 e-mail: anne.barton@manchester.ac.uk
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