Brief Communication abstract
Nature Genetics 40, 1153 - 1155 (2008)
Published online: 31 August 2008 | doi:10.1038/ng.214
Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12
Jielin Sun1,2,11, Siqun Lilly Zheng1,2,11, Fredrik Wiklund3, Sarah D Isaacs4, Lina D Purcell1,2, Zhengrong Gao1,2, Fang-Chi Hsu1,5, Seong-Tae Kim1,2, Wennuan Liu1,2, Yi Zhu1,2, Pär Stattin6, Hans-Olov Adami3,7, Kathleen E Wiley4, Latchezar Dimitrov1,2, Jishan Sun1,2, Tao Li1,2, Aubrey R Turner1,2, Tamara S Adams1,2, Jan Adolfsson8, Jan-Erik Johansson9, James Lowey10, Bruce J Trock4, Alan W Partin4, Patrick C Walsh4, Jeffrey M Trent10, David Duggan10, John Carpten10, Bao-Li Chang1,2, Henrik Grönberg3, William B Isaacs4 & Jianfeng Xu1,2
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, 
26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 
10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
- Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
- Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
- Department of Medical Epidemiology and Biostatistics, CLINTEC, Karolinska Institute, Stockholm SE-17177, Sweden.
- Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
- Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
- Department of Surgical and Perioperative sciences, Urology and Andrology, Umeå University Hospital, Umeå SE-90787, Sweden.
- Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
- Oncological Center, CLINTEC, Karolinska Institutet, Stockholm SE-17177, Sweden.
- Department of Urology, Örebro University Hospital, Örebro SE-70182, Sweden.
- Translational Genomics Research Institute, Phoenix, Arizona 85004, USA.
- These authors contributed equally to this work.
Correspondence to: William B Isaacs4 e-mail: wisaacs@jhmi.edu
Correspondence to: Henrik Grönberg3 e-mail: henrik.gronberg@ki.se
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiencyGenes and Immunity Original Article
Common variations in BARD1 influence susceptibility to high-risk neuroblastomaNature Genetics Letter (01 Jun 2009)
Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong ChineseGenes and Immunity Original Article
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1Nature Genetics Letter (01 May 2008)
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosusNature Genetics Letter (01 Feb 2008)
See all 16 matches for Research
