Brief Communication abstract
Nature Genetics 40, 1160 - 1162 (2008)
Published online: 7 September 2008 | doi:10.1038/ng.210
Common variants of FUT2 are associated with plasma vitamin B12 levels
Aditi Hazra1,2, Peter Kraft1, Jacob Selhub3, Edward L Giovannucci2,4, Gilles Thomas5, Robert N Hoover5, Stephen J Chanock5 & David J Hunter1,2,4,5,6
We identified a strong association (P = 5.36 
10-17) between rs492602 in FUT2 and plasma vitamin B12 levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B12 levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B12 absorption and plasma levels.
- Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA.
- Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA.
- Vitamin Metabolism and Aging Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA.
- Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA.
- Division of Cancer Epidemiology and Genetics, National Cancer Institute(NCI), US National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland 20892, USA.
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Correspondence to: David J Hunter1,2,4,5,6 e-mail: dhunter@hsph.harvard.edu
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