Breast tumors with deficiency in DNA double-strand break repair might be expected to show aneuploidy. A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers.
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Foulkes, W. BRCA1—sowing the seeds crooked in the furrow. Nat Genet 40, 8–9 (2008). https://doi.org/10.1038/ng0108-8
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DOI: https://doi.org/10.1038/ng0108-8
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