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Letter

Nature Genetics 40, 102–107 (1 January 2008) | doi:10.1038/ng.2007.39

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair

Lao H Saal , Sofia K Gruvberger-Saal , Camilla Persson , Kristina L|[ouml]|vgren , Mervi Jumppanen , Johan Staaf , G|[ouml]|ran J|[ouml]|nsson , Maira M Pires , Matthew Maurer , Karolina Holm , Susan Koujak , Shivakumar Subramaniyam , Johan Vallon-Christersson , H|[aring]|kan Olsson , Tao Su , Lorenzo Memeo , Thomas Ludwig , Stephen P Ethier , Morten Krogh , Matthias Szabolcs , Vundavalli VVS Murty , Jorma Isola , Hanina Hibshoosh , Ramon Parsons & |[Aring]|ke Borg

Basal-like breast cancer (BBC) is a subtype of breast cancer with poor prognosis. Inherited mutations of BRCA1, a cancer susceptibility gene involved in double-strand DNA break (DSB) repair, lead to breast cancers that are nearly always of the BBC subtype; however, the precise molecular lesions and oncogenic consequences of BRCA1 dysfunction are poorly understood.