News and Views
Nature Genetics 40, 6 - 7 (2008)
doi:10.1038/ng0108-6
Genomic rearrangements in the spotlight
Lucy R Osborne1
- Lucy R. Osborne is in the Departments of Medicine and Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada. e-mail: lucy.osborne@utoronto.ca
Abstract
Aberrant meiotic recombination can result in disease-causing chromosome microdeletions or microduplications. A new study of several disease-associated recombination hot spots in male germ cells shows that some genomic rearrangements, particularly microduplications, are significantly underdiagnosed.
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