Brief Communication abstract
Nature Genetics 40, 29 - 31 (2008)
Published online: 16 December 2007 | doi:10.1038/ng.2007.52
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
Michael A van Es1,15, Paul WJ van Vught1,15, Hylke M Blauw1,15, Lude Franke2,15, Christiaan GJ Saris1, Ludo Van Den Bosch3, Sonja W de Jong1, Vianney de Jong4, Frank Baas5, Ruben van't Slot2, Robin Lemmens3, Helenius J Schelhaas6, Anna Birve7, Kristel Sleegers8,9, Christine Van Broeckhoven8,9, Jennifer C Schymick10, Bryan J Traynor11, John HJ Wokke1, Cisca Wijmenga2,12, Wim Robberecht3, Peter M Andersen7, Jan H Veldink1, Roel A Ophoff13,14 & Leonard H van den Berg1
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 
10-
8 in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18–1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
- Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
- Complex Genetics Section, Department of Biomedical Genetics, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
- Department of Neurology, University Hospital Gasthuisberg, Leuven B-3000, Belgium.
- Department of Neurology, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
- Department of Neurogenetics, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands.
- Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands.
- Institute of Clinical Neuroscience, Umeå University Hospital, Umeå SE-901 85, Sweden.
- Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen B-2610, Belgium.
- University of Antwerp, Antwerpen B-2610, Belgium.
- Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
- Section on Developmental Genetic Epidemiology, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
- Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands.
- Department of Medical Genetics and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
- Neuropsychiatric Institute, University of California, Los Angeles, California 90095, USA.
- These authors contributed equally to this work.
Correspondence to: Leonard H van den Berg1 e-mail: L.H.vandenBerg@umcutrecht.nl
Correspondence to: Roel A Ophoff13,14 e-mail: Ophoff@ucla.edu
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