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Volume 40 Issue 1, January 2008

Cover Art: Chromosome Socks by Gina Glover http://www.ginaglover.com/ From the exhibition 'Gregor Mendel: Planting the Seeds of Genetics' http://www.fieldmuseum.org/mendel/tour.asp

Volume 40 Issue 1

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Editorial

  • The journal has now begun to commission reviews on variation at selected loci as a way to demonstrate that microattribution can produce the required incentive for high-quality community annotation of the human genome.

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Book Review

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News & Views

  • Accurate measurements of genomic copy number polymorphisms are required to define their medical relevance, but obtaining such measurements for multiallelic copy number variants has been challenging. A copy-number study of psoriasis now sets some useful precedents for a maturing field.

    • Steven A McCarroll
    News & Views

  • Aberrant meiotic recombination can result in disease-causing chromosome microdeletions or microduplications. A new study of several disease-associated recombination hot spots in male germ cells shows that some genomic rearrangements, particularly microduplications, are significantly underdiagnosed.

    • Lucy R Osborne
    News & Views

  • Breast tumors with deficiency in DNA double-strand break repair might be expected to show aneuploidy. A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers.

    • William D Foulkes
    News & Views

  • Primary cilia and planar cell polarity (PCP) proteins both contribute to cell polarization, but their relationship is unclear. A new study shows that, in the organ of Corti, primary cilia are required for morphological polarization of sensory hair cells and function downstream of the PCP signaling proteins.

    • Jeffrey D Axelrod
    News & Views
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Perspective

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Brief Communication

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Article

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Letter

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