Nature Genetics
4, 175 - 180 (1993)
doi:10.1038/ng0693-175
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcomaT.H. Rabbitts1, A. Forster1, R. Larson1
& P. Nathan1
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK Correspondence should be addressed to T.H.R. The search for tumour−specific markers is one of the chief goals in cancer biology. We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can result in fusion of the FUS glycine−rich protein with the whole CHOP coding region. The data support the concept that protein fusion may commonly occur in solid tumours resulting in tumour−specific markers of potential clinical importance. The data also indicate the importance of transcription disruption in the pathogenesis of solid tumours.
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