Article abstract
Nature Genetics 39, 1100 - 1107 (2007)
Published online: 29 July 2007 | doi:10.1038/ng2087
On the subspecific origin of the laboratory mouse
Hyuna Yang1, Timothy A Bell2, Gary A Churchill1 & Fernando Pardo-Manuel de Villena2
Abstract
The genome of the laboratory mouse is thought to be a mosaic of regions with distinct subspecific origins. We have developed a high-resolution map of the origin of the laboratory mouse by generating 25,400 phylogenetic trees at 100-kb intervals spanning the genome. On average, 92% of the genome is of Mus musculus domesticus origin, and the distribution of diversity is markedly nonrandom among the chromosomes. There are large regions of extremely low diversity, which represent blind spots for studies of natural variation and complex traits, and hot spots of diversity. In contrast with the mosaic model, we found that most of the genome has intermediate levels of variation of intrasubspecific origin. Finally, mouse strains derived from the wild that are supposed to represent different mouse subspecies show substantial intersubspecific introgression, which has strong implications for evolutionary studies that assume these are pure representatives of a given subspecies.
- The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
- Department of Genetics, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Correspondence to: Fernando Pardo-Manuel de Villena2 e-mail: fernando@med.unc.edu
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