Compete, collaborate, compel - p931

doi:10.1038/ng0807-931

Full Text - Compete, collaborate, compel | PDF (84 KB) - Compete, collaborate, compel

Splinkerette PCR for more efficient characterization of gene trap events - pp933 - 934

Carsten Horn, Jens Hansen, Frank Schnütgen, Claudia Seisenberger, Thomas Floss, Markus Irgang, Silke De-Zolt, Wolfgang Wurst, Harald von Melchner & Patricia Ruiz Noppinger

doi:10.1038/ng0807-933

Full Text - Splinkerette PCR for more efficient characterization of gene trap events | PDF (179 KB) - Splinkerette PCR for more efficient characterization of gene trap events | Supplementary information

Target mimics modulate miRNAs - pp935 - 936

Daniel H Chitwood & Marja C P Timmermans

doi:10.1038/ng0807-935

Full Text - Target mimics modulate miRNAs | PDF (140 KB) - Target mimics modulate miRNAs

See also: Letter by Franco-Zorrilla et al.

Axons need glial peroxisomes - pp936 - 938

Patrick Aubourg

doi:10.1038/ng0807-936

Full Text - Axons need glial peroxisomes | PDF (300 KB) - Axons need glial peroxisomes

See also: Article by Kassmann et al.

A step forward for restless legs syndrome - pp938 - 939

Emmanuel Mignot

doi:10.1038/ng0807-938

Full Text - A step forward for restless legs syndrome | PDF (105 KB) - A step forward for restless legs syndrome

See also: Letter by Winkelmann et al.

Touching base - p941

doi:10.1038/ng0807-941

Full Text - Touching base | PDF (91 KB) - Touching base

Research Highlights - p943

doi:10.1038/ng0807-943

Full Text - Research Highlights | PDF (71 KB) - Research Highlights

Evolution of chromosome organization driven by selection for reduced gene expression noise - pp945 - 949

Nizar N Batada & Laurence D Hurst

doi:10.1038/ng2071

Abstract - Evolution of chromosome organization driven by selection for reduced gene expression noise | Full Text - Evolution of chromosome organization driven by selection for reduced gene expression noise | PDF (562 KB) - Evolution of chromosome organization driven by selection for reduced gene expression noise | Supplementary information

Common variants in WFS1 confer risk of type 2 diabetes - pp951 - 953

Manjinder S Sandhu, Michael N Weedon, Katherine A Fawcett, Jon Wasson, Sally L Debenham, Allan Daly, Hana Lango, Timothy M Frayling, Rosalind J Neumann, Richard Sherva, Ilana Blech, Paul D Pharoah, Colin N A Palmer, Charlotte Kimber, Roger Tavendale, Andrew D Morris, Mark I McCarthy, Mark Walker, Graham Hitman, Benjamin Glaser, M Alan Permutt, Andrew T Hattersley, Nicholas J Wareham & Inês Barroso

doi:10.1038/ng2067

Abstract - Common variants in : WFS1: confer risk of type 2 diabetes | Full Text - Common variants in WFS1 confer risk of type 2 diabetes | PDF (133 KB) - Common variants in WFS1 confer risk of type 2 diabetes | Supplementary information

A common genetic risk factor for colorectal and prostate cancer - pp954 - 956

Christopher A Haiman, Loïc Le Marchand, Jennifer Yamamato, Daniel O Stram, Xin Sheng, Laurence N Kolonel, Anna H Wu, David Reich & Brian E Henderson

doi:10.1038/ng2098

Abstract - A common genetic risk factor for colorectal and prostate cancer | Full Text - A common genetic risk factor for colorectal and prostate cancer | PDF (140 KB) - A common genetic risk factor for colorectal and prostate cancer | Supplementary information

Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes - pp957 - 959

Sibel Kantarci, Lihadh Al-Gazali, R Sean Hill, Dian Donnai, Graeme C M Black, Eric Bieth, Nicolas Chassaing, Didier Lacombe, Koen Devriendt, Ahmad Teebi, Maria Loscertales, Caroline Robson, Tianming Liu, David T MacLaughlin, Kristin M Noonan, Meaghan K Russell, Christopher A Walsh, Patricia K Donahoe & Barbara R Pober

doi:10.1038/ng2063

Abstract - Mutations in : LRP2: , which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes | Full Text - Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes | PDF (236 KB) - Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes | Supplementary information

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL - pp960 - 962

Cristina Sobacchi, Annalisa Frattini, Matteo M Guerrini, Mario Abinun, Alessandra Pangrazio, Lucia Susani, Robbert Bredius, Grazia Mancini, Andrew Cant, Nick Bishop, Peter Grabowski, Andrea Del Fattore, Chiara Messina, Gabriella Errigo, Fraser P Coxon, Debbie I Scott, Anna Teti, Michael J Rogers, Paolo Vezzoni, Anna Villa & Miep H Helfrich

doi:10.1038/ng2076

Abstract - Osteoclast-poor human osteopetrosis due to mutations in the gene encoding : RANKL | Full Text - Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL | PDF (204 KB) - Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL | Supplementary information

Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth - pp963 - 965

Jenny Douglas, Deirdre Cilliers, Kim Coleman, Katrina Tatton-Brown, Karen Barker, Brigitte Bernhard, John Burn, Susan Huson, Dragana Josifova, Didier Lacombe, Mohsin Malik, Sahar Mansour, Evan Reid, Valerie Cormier-Daire, Trevor Cole, The Childhood Overgrowth Collaboration & Nazneen Rahman

doi:10.1038/ng2083

Abstract - Mutations in : RNF135: , a gene within the : NF1: microdeletion region, cause phenotypic abnormalities including overgrowth | Full Text - Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth | PDF (194 KB) - Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth | Supplementary information

Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice - pp966 - 968

Anna Kouznetsova, Lisa Lister, Magnus Nordenskjöld, Mary Herbert & Christer Höög

doi:10.1038/ng2065

Abstract - Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice | Full Text - Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice | PDF (282 KB) - Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice | Supplementary information

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes - pp969 - 976

Celia M Kassmann, Corinna Lappe-Siefke, Myriam Baes, Britta Brügger, Alexander Mildner, Hauke B Werner, Oliver Natt, Thomas Michaelis, Marco Prinz, Jens Frahm & Klaus-Armin Nave

doi:10.1038/ng2070

Abstract - Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes | Full Text - Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes | PDF (586 KB) - Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes | Supplementary information

See also: News and Views by Aubourg

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes - pp977 - 983

Julius Gudmundsson, Patrick Sulem, Valgerdur Steinthorsdottir, Jon T Bergthorsson, Gudmar Thorleifsson, Andrei Manolescu, Thorunn Rafnar, Daniel Gudbjartsson, Bjarni A Agnarsson, Adam Baker, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Margret Jakobsdottir, Thorarinn Blondal, Simon N Stacey, Agnar Helgason, Steinunn Gunnarsdottir, Adalheidur Olafsdottir, Kari T Kristinsson, Birgitta Birgisdottir, Shyamali Ghosh, Steinunn Thorlacius, Dana Magnusdottir, Gerdur Stefansdottir, Kristleifur Kristjansson, Yu Bagger, Robert L Wilensky, Muredach P Reilly, Andrew D Morris, Charlotte H Kimber, Adebowale Adeyemo, Yuanxiu Chen, Jie Zhou, Wing-Yee So, Peter C Y Tong, Maggie C Y Ng, Torben Hansen, Gitte Andersen, Knut Borch-Johnsen, Torben Jorgensen, Alejandro Tres, Fernando Fuertes, Manuel Ruiz-Echarri, Laura Asin, Berta Saez, Erica van Boven, Siem Klaver, Dorine W Swinkels, Katja K Aben, Theresa Graif, John Cashy, Brian K Suarez, Onco van Vierssen Trip, Michael L Frigge, Carole Ober, Marten H Hofker, Cisca Wijmenga, Claus Christiansen, Daniel J Rader, Colin N A Palmer, Charles Rotimi, Juliana C N Chan, Oluf Pedersen, Gunnar Sigurdsson, Rafn Benediktsson, Eirikur Jonsson, Gudmundur V Einarsson, Jose I Mayordomo, William J Catalona, Lambertus A Kiemeney, Rosa B Barkardottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong & Kari Stefansson

doi:10.1038/ng2062

First paragraph - Two variants on chromosome 17 confer prostate cancer risk, and the one in : TCF2: protects against type 2 diabetes | Full Text - Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes | PDF (263 KB) - Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes | Supplementary information

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 - pp984 - 988

Ian Tomlinson, Emily Webb, Luis Carvajal-Carmona, Peter Broderick, Zoe Kemp, Sarah Spain, Steven Penegar, Ian Chandler, Maggie Gorman, Wendy Wood, Ella Barclay, Steven Lubbe, Lynn Martin, Gabrielle Sellick, Emma Jaeger, Richard Hubner, Ruth Wild, Andrew Rowan, Sarah Fielding, Kimberley Howarth, the CORGI Consortium, Andrew Silver, Wendy Atkin, Kenneth Muir, Richard Logan, David Kerr, Elaine Johnstone, Oliver Sieber, Richard Gray, Huw Thomas, Julian Peto, Jean-Baptiste Cazier & Richard Houlston

doi:10.1038/ng2085

First paragraph - A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 | Full Text - A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 | PDF (293 KB) - A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 | Supplementary information

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 - pp989 - 994

Brent W Zanke, Celia MT Greenwood, Jagadish Rangrej, Rafal Kustra, Albert Tenesa, Susan M Farrington, James Prendergast, Sylviane Olschwang, Theodore Chiang, Edgar Crowdy, Vincent Ferretti, Philippe Laflamme, Saravanan Sundararajan, Stéphanie Roumy, Jean-François Olivier, Frédérick Robidoux, Robert Sladek, Alexandre Montpetit, Peter Campbell, Stephane Bezieau, Anne Marie O'Shea, George Zogopoulos, Michelle Cotterchio, Polly Newcomb, John McLaughlin, Ban Younghusband, Roger Green, Jane Green, Mary E M Porteous, Harry Campbell, Helene Blanche, Mourad Sahbatou, Emmanuel Tubacher, Catherine Bonaiti-Pellié, Bruno Buecher, Elio Riboli, Sebastien Kury, Stephen J Chanock, John Potter, Gilles Thomas, Steven Gallinger, Thomas J Hudson & Malcolm G Dunlop

doi:10.1038/ng2089

First paragraph - Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 | Full Text - Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 | PDF (258 KB) - Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 | Supplementary information

A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease - pp995 - 999

Stephan Buch, Clemens Schafmayer, Henry Völzke, Christian Becker, Andre Franke, Huberta von Eller-Eberstein, Christian Kluck, Ingelore Bässmann, Mario Brosch, Frank Lammert, Juan Francisco Miquel, Flavio Nervi, Michael Wittig, Dieter Rosskopf, Birgit Timm, Christine Höll, Marcus Seeger, Abdou ElSharawy, Tim Lu, Jan Egberts, Fred Fändrich, Ulrich R Fölsch, Michael Krawczak, Stefan Schreiber, Peter Nürnberg, Jürgen Tepel & Jochen Hampe

doi:10.1038/ng2101

Abstract - A genome-wide association scan identifies the hepatic cholesterol transporter : ABCG8: as a susceptibility factor for human gallstone disease | Full Text - A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease | PDF (254 KB) - A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease | Supplementary information

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions - pp1000 - 1006

Juliane Winkelmann, Barbara Schormair, Peter Lichtner, Stephan Ripke, Lan Xiong, Shapour Jalilzadeh, Stephany Fulda, Benno Pütz, Gertrud Eckstein, Stephanie Hauk, Claudia Trenkwalder, Alexander Zimprich, Karin Stiasny-Kolster, Wolfgang Oertel, Cornelius G Bachmann, Walter Paulus, Ines Peglau, Ilonka Eisensehr, Jacques Montplaisir, Gustavo Turecki, Guy Rouleau, Christian Gieger, Thomas Illig, H-Erich Wichmann, Florian Holsboer, Bertram Müller-Myhsok & Thomas Meitinger

doi:10.1038/ng2099

First paragraph - Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions | Full Text - Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions | PDF (526 KB) - Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions | Supplementary information

See also: News and Views by Mignot

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy - pp1007 - 1012

Bhaswati Pandit, Anna Sarkozy, Len A Pennacchio, Claudio Carta, Kimihiko Oishi, Simone Martinelli, Edgar A Pogna, Wendy Schackwitz, Anna Ustaszewska, Andrew Landstrom, J Martijn Bos, Steve R Ommen, Giorgia Esposito, Francesca Lepri, Christian Faul, Peter Mundel, Juan P López Siguero, Romano Tenconi, Angelo Selicorni, Cesare Rossi, Laura Mazzanti, Isabella Torrente, Bruno Marino, Maria C Digilio, Giuseppe Zampino, Michael J Ackerman, Bruno Dallapiccola, Marco Tartaglia & Bruce D Gelb

doi:10.1038/ng2073

First paragraph - Gain-of-function : RAF1: mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy | Full Text - Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy | PDF (224 KB) - Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy | Supplementary information

Germline gain-of-function mutations in RAF1 cause Noonan syndrome - pp1013 - 1017

M Abdur Razzaque, Tsutomu Nishizawa, Yuta Komoike, Hisato Yagi, Michiko Furutani, Ryunosuke Amo, Mitsuhiro Kamisago, Kazuo Momma, Hiroshi Katayama, Masao Nakagawa, Yuko Fujiwara, Masaki Matsushima, Katsumi Mizuno, Mika Tokuyama, Hamao Hirota, Jun Muneuchi, Toru Higashinakagawa & Rumiko Matsuoka

doi:10.1038/ng2078

First paragraph - Germline gain-of-function mutations in : RAF1: cause Noonan syndrome | Full Text - Germline gain-of-function mutations in RAF1 cause Noonan syndrome | PDF (350 KB) - Germline gain-of-function mutations in RAF1 cause Noonan syndrome | Supplementary information

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis - pp1018 - 1024

Massimo Attanasio, N Henriette Uhlenhaut, Vitor H Sousa, John F O'Toole, Edgar Otto, Katrin Anlag, Claudia Klugmann, Anna-Corina Treier, Juliana Helou, John A Sayer, Dominik Seelow, Gudrun Nürnberg, Christian Becker, Albert E Chudley, Peter Nürnberg, Friedhelm Hildebrandt & Mathias Treier

doi:10.1038/ng2072

First paragraph - Loss of : : GLIS2: : causes nephronophthisis in humans and mice by increased apoptosis and fibrosis | Full Text - Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis | PDF (845 KB) - Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis | Supplementary information

Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice - pp1025 - 1032

Fudi Wang, Prasad N Paradkar, Angel O Custodio, Diane McVey Ward, Mark D Fleming, Dean Campagna, Kristina A Roberts, Victor Boyartchuk, William F Dietrich, Jerry Kaplan & Nancy C Andrews

doi:10.1038/ng2059

First paragraph - Genetic variation in : Mon1a: affects protein trafficking and modifies macrophage iron loading in mice | Full Text - Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice | PDF (722 KB) - Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice | Supplementary information

Target mimicry provides a new mechanism for regulation of microRNA activity - pp1033 - 1037

José Manuel Franco-Zorrilla, Adrián Valli, Marco Todesco, Isabel Mateos, María Isabel Puga, Ignacio Rubio-Somoza, Antonio Leyva, Detlef Weigel, Juan Antonio García & Javier Paz-Ares

doi:10.1038/ng2079

First paragraph - Target mimicry provides a new mechanism for regulation of microRNA activity | Full Text - Target mimicry provides a new mechanism for regulation of microRNA activity | PDF (390 KB) - Target mimicry provides a new mechanism for regulation of microRNA activity | Supplementary information

See also: News and Views by Chitwood & Timmermans