Access

Letter

Nature Genetics 39, 989–994 (1 August 2007) | doi:10.1038/ng2089

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

Brent W Zanke , Celia MT Greenwood , Jagadish Rangrej , Rafal Kustra , Albert Tenesa , Susan M Farrington , James Prendergast , Sylviane Olschwang , Theodore Chiang , Edgar Crowdy , Vincent Ferretti , Philippe Laflamme , Saravanan Sundararajan , St|[eacute]|phanie Roumy , Jean-Fran|[ccedil]|ois Olivier , Fr|[eacute]|d|[eacute]|rick Robidoux , Robert Sladek , Alexandre Montpetit , Peter Campbell , Stephane Bezieau , Anne Marie O'Shea , George Zogopoulos , Michelle Cotterchio , Polly Newcomb , John McLaughlin , Ban Younghusband , Roger Green , Jane Green , Mary E M Porteous , Harry Campbell , Helene Blanche , Mourad Sahbatou , Emmanuel Tubacher , Catherine Bonaiti-Pelli|[eacute]| , Bruno Buecher , Elio Riboli , Sebastien Kury , Stephen J Chanock , John Potter , Gilles Thomas , Steven Gallinger , Thomas J Hudson & Malcolm G Dunlop

Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario.