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Letter

Nature Genetics 39, 1033–1037 (1 August 2007) | doi:10.1038/ng2079

Target mimicry provides a new mechanism for regulation of microRNA activity

Jos|[eacute]| Manuel Franco-Zorrilla , Adri|[aacute]|n Valli , Marco Todesco , Isabel Mateos , Mar|[iacute]|a Isabel Puga , Ignacio Rubio-Somoza , Antonio Leyva , Detlef Weigel , Juan Antonio Garc|[iacute]|a & Javier Paz-Ares

MicroRNAs (miRNA) regulate key aspects of development and physiology in animals and plants. These regulatory RNAs act as guides of effector complexes to recognize specific mRNA sequences based on sequence complementarity, resulting in translational repression or site-specific cleavage.