Access

Letter

Nature Genetics 39, 977–983 (1 August 2007) | doi:10.1038/ng2062

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

Julius Gudmundsson , Patrick Sulem , Valgerdur Steinthorsdottir , Jon T Bergthorsson , Gudmar Thorleifsson , Andrei Manolescu , Thorunn Rafnar , Daniel Gudbjartsson , Bjarni A Agnarsson , Adam Baker , Asgeir Sigurdsson , Kristrun R Benediktsdottir , Margret Jakobsdottir , Thorarinn Blondal , Simon N Stacey , Agnar Helgason , Steinunn Gunnarsdottir , Adalheidur Olafsdottir , Kari T Kristinsson , Birgitta Birgisdottir , Shyamali Ghosh , Steinunn Thorlacius , Dana Magnusdottir , Gerdur Stefansdottir , Kristleifur Kristjansson , Yu Bagger , Robert L Wilensky , Muredach P Reilly , Andrew D Morris , Charlotte H Kimber , Adebowale Adeyemo , Yuanxiu Chen , Jie Zhou , Wing-Yee So , Peter C Y Tong , Maggie C Y Ng , Torben Hansen , Gitte Andersen , Knut Borch-Johnsen , Torben Jorgensen , Alejandro Tres , Fernando Fuertes , Manuel Ruiz-Echarri , Laura Asin , Berta Saez , Erica van Boven , Siem Klaver , Dorine W Swinkels , Katja K Aben , Theresa Graif , John Cashy , Brian K Suarez , Onco van Vierssen Trip , Michael L Frigge , Carole Ober , Marten H Hofker , Cisca Wijmenga , Claus Christiansen , Daniel J Rader , Colin N A Palmer , Charles Rotimi , Juliana C N Chan , Oluf Pedersen , Gunnar Sigurdsson , Rafn Benediktsson , Eirikur Jonsson , Gudmundur V Einarsson , Jose I Mayordomo , William J Catalona , Lambertus A Kiemeney , Rosa B Barkardottir , Jeffrey R Gulcher , Unnur Thorsteinsdottir , Augustine Kong & Kari Stefansson

We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease.