Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Axons need glial peroxisomes

Nature Genetics volume 39, pages 936–938 (2007)Cite this article

Several devastating genetic diseases illustrate that peroxisomes are essential to the development and functioning of the central nervous system. New work using a mouse model now shows that peroxisome integrity in oligodendrocytes is essential for axonal maintenance.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Oligodendrocyte peroxisomes.

References

  1. Wanders, R.J.A. & Waterham, H. Annu. Rev. Biochem. 75, 295–332 (2006).

    Article  CAS  Google Scholar 

  2. Kassmann, C.M. et al. Nat Genet. 39, 969–976 (2007).

    Article  CAS  Google Scholar 

  3. Lappe-Siefke, C. et al. Nat. Genet. 33, 366–374 (2003).

    Article  CAS  Google Scholar 

  4. Dubois-Dalcq, M., Feigenbaum, V. & Aubourg, P. Trends Neurosci. 22, 4–12 (1999).

    Article  CAS  Google Scholar 

  5. Pujol, A. et al. Hum. Mol. Genet. 11, 499–505 (2002).

    Article  CAS  Google Scholar 

  6. Pujol, A. et al. J. Neurochem. 101 (Suppl.), 66 (2007).

    Google Scholar 

  7. Goldfischer, S. et al. Science 182, 62–64 (1973).

    Article  CAS  Google Scholar 

  8. Ito, M. et al. J. Neuropathol. Exp. Neurol. 60, 1004–1019 (2001).

    Article  CAS  Google Scholar 

  9. Johnson, A.J. et al. Int. Rev. Neurobiol. 79, 73–97 (2007).

    Article  CAS  Google Scholar 

  10. Brisebois, M. et al. J. Immunol. 177, 2403–2411 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Neurology, Patrick Aubourg is at INSERM U745, Hôpital Saint-Vincent de Paul, University René Descartes, Paris 75014, France. aubourg@paris5.inserm.fr,

    Patrick Aubourg

Authors
  1. Patrick Aubourg
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aubourg, P. Axons need glial peroxisomes. Nat Genet 39, 936–938 (2007). https://doi.org/10.1038/ng0807-936

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0807-936

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing