Brief Communication abstract
Nature Genetics 39, 966 - 968 (2007)
Published online: 8 July 2007 | doi:10.1038/ng2065
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice
Anna Kouznetsova1, Lisa Lister2, Magnus Nordenskjöld3, Mary Herbert2 & Christer Höög1
The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes (univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes.
- Department of Cell and Molecular Biology, Karolinska Institutet, S-171 77, Stockholm, Sweden.
- Newcastle Fertility Centre, Institute of Human Genetics and North East England Stem Cell Institute, Newcastle University, Bioscience Building, International Centre for Life, Newcastle upon Tyne NE1 4EP, UK.
- Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska University Hospital, 171 76 Solna, Sweden.
Correspondence to: Christer Höög1 e-mail: christer.hoog@ki.se
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