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Letter

Nature Genetics 39, 857–864 (1 July 2007) | doi:10.1038/ng2068

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

John A Todd , Neil M Walker , Jason D Cooper , Deborah J Smyth , Kate Downes , Vincent Plagnol , Rebecca Bailey , Sergey Nejentsev , Sarah F Field , Felicity Payne , Christopher E Lowe , Jeffrey S Szeszko , Jason P Hafler , Lauren Zeitels , Jennie H M Yang , Adrian Vella , Sarah Nutland , Helen E Stevens , Helen Schuilenburg , Gillian Coleman , Meeta Maisuria , William Meadows , Luc J Smink , Barry Healy , Oliver S Burren , Alex A C Lam , Nigel R Ovington , James Allen , Ellen Adlem , Hin-Tak Leung , Chris Wallace , Joanna M M Howson , Cristian Guja , Constantin Ionescu-T|[icirc]|rgovi|[scedil]|te , Matthew J Simmonds , Joanne M Heward , Stephen C L Gough , David B Dunger , Linda S Wicker & David G Clayton

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P |[minus]|7 between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study.