Access

Brief Communication

Nature Genetics 39, 827–829 (1 July 2007) | doi:10.1038/ng2058

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

David A van Heel , Lude Franke , Karen A Hunt , Rhian Gwilliam , Alexandra Zhernakova , Mike Inouye , Martin C Wapenaar , Martin C N M Barnardo , Graeme Bethel , Geoffrey K T Holmes , Con Feighery , Derek Jewell , Dermot Kelleher , Parveen Kumar , Simon Travis , Julian RF Walters , David S Sanders , Peter Howdle , Jill Swift , Raymond J Playford , William M McLaren , M Luisa Mearin , Chris J Mulder , Ross McManus , Ralph McGinnis , Lon R Cardon , Panos Deloukas & Cisca Wijmenga

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 |[times]| 10|[minus]|7) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block.