News and Views


Nature Genetics 39, 813 - 815 (2007)
doi:10.1038/ng0707-813

Guilt beyond a reasonable doubt

David Altshuler1 & Mark Daly1

  1. David Altshuler and Mark Daly are at Massachusetts General Hospital, Harvard Medical School and the Broad Institute of Harvard and MIT, Boston, Massachusetts, USA. e-mail: altshuler@molbio.mgh.harvard.edu and e-mail: mjdaly@chgr.mgh.harvard.edu


Genome-wide association studies, exemplified by the Wellcome Trust Case Control Consortium and follow-up studies, have identified dozens of common variants robustly associated with common diseases, providing new clues about genetic architecture in humans. Finding all such loci, and fully defining genotype-phenotype correlation, will be a key to translating initial clues into pathophysiological understanding and clinical prediction.

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