Advancing the spark - p689

doi:10.1038/ng0607-689

Full Text - Advancing the spark | PDF (88 KB) - Advancing the spark

Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection - pp691 - 692

Nelson Leung-Sang Tang, Paul Kay-Sheung Chan, David Shu-Cheong Hui, Ka-Fai To, Weimin Zhang, Francis K L Chan, Joseph Jao-Yiu Sung & Yuk Ming Dennis Lo

doi:10.1038/ng0607-691

Full Text - Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection | PDF (46 KB) - Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection | Supplementary information

Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection - pp692 - 693

Lianteng Zhi, Gangqiao Zhou, Hongxing Zhang, Yun Zhai, Hao Yang, Fang Zhang, Shixin Wang, Maoti Wei, Wuchun Cao & Fuchu He

doi:10.1038/ng0607-692

Full Text - Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection | PDF (57 KB) - Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection | Supplementary information

Reply to "Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection" - pp694 - 696

Kelvin Y K Chan, Vera S F Chan, Yongxiong Chen, Shea-Ping Yip, Chen-Lung S Lin & Ui-Soon Khoo

doi:10.1038/ng0607-694

Full Text - Reply to "Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection" | PDF (145 KB) - Reply to "Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection" | Supplementary information

DNA double-strand breaks are not sufficient to initiate recruitment of TRF2 - pp696 - 698

Eli S Williams, Jan Stap, Jeroen Essers, Brian Ponnaiya, Martijn S Luijsterburg, Przemek M Krawczyk, Robert L Ullrich, Jacob A Aten & Susan M Bailey

doi:10.1038/ng0607-696

Full Text - DNA double-strand breaks are not sufficient to initiate recruitment of TRF2 | PDF (249 KB) - DNA double-strand breaks are not sufficient to initiate recruitment of TRF2 | Supplementary information

Reply to "DNA double-strand breaks are not sufficient to initiate recruitment of TRF2" - pp698 - 699

Paul S Bradshaw & M Stephen Meyn

doi:10.1038/ng0607-698

Full Text - Reply to "DNA double-strand breaks are not sufficient to initiate recruitment of TRF2" | PDF (41 KB) - Reply to "DNA double-strand breaks are not sufficient to initiate recruitment of TRF2"

A general theory of gene sharing - p701

doi:10.1038/ng0607-701

Full Text - A general theory of gene sharing | PDF (57 KB) - A general theory of gene sharing

Ribonucleotide reductase and mitochondrial DNA synthesis - pp703 - 704

Lars Thelander

doi:10.1038/ng0607-703

Full Text - Ribonucleotide reductase and mitochondrial DNA synthesis | PDF (346 KB) - Ribonucleotide reductase and mitochondrial DNA synthesis

See also: Letter by Bourdon et al.

Evolutionary conservation in myoblast fusion - pp704 - 705

Robert S Krauss

doi:10.1038/ng0607-704

Full Text - Evolutionary conservation in myoblast fusion | PDF (143 KB) - Evolutionary conservation in myoblast fusion

See also: Letter by Srinivas et al.

From fused toes in mice to human obesity - pp706 - 707

Leif Groop

doi:10.1038/ng0607-706

Full Text - From fused toes in mice to human obesity | PDF (126 KB) - From fused toes in mice to human obesity

See also: Brief Communication by Dina et al.

Scarce but scary - pp707 - 708

Anja-Katrin Bielinsky

doi:10.1038/ng0607-707

Full Text - Scarce but scary | PDF (125 KB) - Scarce but scary

See also: Letter by Pennington & Rosenberg

'Unleashed' natural killers hinder HIV - pp708 - 710

Marcus Altfeld & Philip Goulder

doi:10.1038/ng0607-708

Full Text - 'Unleashed' natural killers hinder HIV | PDF (272 KB) - 'Unleashed' natural killers hinder HIV

See also: Letter by Pennington & Rosenberg

Touching base - p711

doi:10.1038/ng0607-711

Full Text - Touching base | PDF (109 KB) - Touching base

Research highlights - p713

doi:10.1038/ng0607-713

Full Text - Research highlights | PDF (42 KB) - Research highlights

Using FlyAtlas to identify better Drosophila melanogaster models of human disease - pp715 - 720

Venkateswara R Chintapalli, Jing Wang & Julian A T Dow

doi:10.1038/ng2049

Abstract - Using FlyAtlas to identify better : Drosophila melanogaster: models of human disease | Full Text - Using FlyAtlas to identify better Drosophila melanogaster models of human disease | PDF (1,165 KB) - Using FlyAtlas to identify better Drosophila melanogaster models of human disease | Supplementary information

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity - pp721 - 723

Manuela Fanciulli, Penny J Norsworthy, Enrico Petretto, Rong Dong, Lorraine Harper, Lavanya Kamesh, Joanne M Heward, Stephen C L Gough, Adam de Smith, Alexandra I F Blakemore, Philippe Froguel, Catherine J Owen, Simon H S Pearce, Luis Teixeira, Loic Guillevin, Deborah S Cunninghame Graham, Charles D Pusey, H Terence Cook, Timothy J Vyse & Timothy J Aitman

doi:10.1038/ng2046

Abstract - : : : FCGR3B: : : copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity | Full Text - FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity | PDF (138 KB) - FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity | Supplementary information

Variation in FTO contributes to childhood obesity and severe adult obesity - pp724 - 726

Christian Dina, David Meyre, Sophie Gallina, Emmanuelle Durand, Antje Körner, Peter Jacobson, Lena M S Carlsson, Wieland Kiess, Vincent Vatin, Cecile Lecoeur, Jérome Delplanque, Emmanuel Vaillant, François Pattou, Juan Ruiz, Jacques Weill, Claire Levy-Marchal, Fritz Horber, Natascha Potoczna, Serge Hercberg, Catherine Le Stunff, Pierre Bougnères, Peter Kovacs, Michel Marre, Beverley Balkau, Stéphane Cauchi, Jean-Claude Chèvre & Philippe Froguel

doi:10.1038/ng2048

Abstract - Variation in : FTO: contributes to childhood obesity and severe adult obesity | Full Text - Variation in FTO contributes to childhood obesity and severe adult obesity | PDF (205 KB) - Variation in FTO contributes to childhood obesity and severe adult obesity | Supplementary information

See also: News and Views by Groop

IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy - pp727 - 729

Philip L Beales, Elizabeth Bland, Jonathan L Tobin, Chiara Bacchelli, Beyhan Tuysuz, Josephine Hill, Suzanne Rix, Chad G Pearson, Masatake Kai, Jane Hartley, Colin Johnson, Melita Irving, Nursel Elcioglu, Mark Winey, Masazumi Tada & Peter J Scambler

doi:10.1038/ng2038

Abstract - IFT80: , which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy | Full Text - IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy | PDF (261 KB) - IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy | Supplementary information

Tissue-specific transcriptional regulation has diverged significantly between human and mouse - pp730 - 732

Duncan T Odom, Robin D Dowell, Elizabeth S Jacobsen, William Gordon, Timothy W Danford, Kenzie D MacIsaac, P Alexander Rolfe, Caitlin M Conboy, David K Gifford & Ernest Fraenkel

doi:10.1038/ng2047

Abstract - Tissue-specific transcriptional regulation has diverged significantly between human and mouse | Full Text - Tissue-specific transcriptional regulation has diverged significantly between human and mouse | PDF (264 KB) - Tissue-specific transcriptional regulation has diverged significantly between human and mouse | Supplementary information

Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 - pp733 - 740

Maureen P Martin, Ying Qi, Xiaojiang Gao, Eriko Yamada, Jeffrey N Martin, Florencia Pereyra, Sara Colombo, Elizabeth E Brown, W Lesley Shupert, John Phair, James J Goedert, Susan Buchbinder, Gregory D Kirk, Amalio Telenti, Mark Connors, Stephen J O'Brien, Bruce D Walker, Peter Parham, Steven G Deeks, Daniel W McVicar & Mary Carrington

doi:10.1038/ng2035

Abstract - Innate partnership of : HLA-B: and : KIR3DL1: subtypes against HIV-1 | Full Text - Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 | PDF (239 KB) - Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 | Supplementary information

See also: News and Views by Altfeld & Goulder

p38 suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway - pp741 - 749

Lijian Hui, Latifa Bakiri, Andreas Mairhorfer, Norbert Schweifer, Christian Haslinger, Lukas Kenner, Vukoslav Komnenovic, Harald Scheuch, Hartmut Beug & Erwin F Wagner

doi:10.1038/ng2033

Abstract - p38[alpha] suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway | Full Text - p38 suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway | PDF (679 KB) - p38 suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway | Supplementary information

p38 MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation - pp750 - 758

Juan José Ventura, Stephan Tenbaum, Eusebio Perdiguero, Marion Huth, Carmen Guerra, Mariano Barbacid, Manolis Pasparakis & Angel R Nebreda

doi:10.1038/ng2037

Abstract - p38[alpha] MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation | Full Text - p38 MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation | PDF (563 KB) - p38 MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation | Supplementary information

MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer - pp759 - 769

Vassiliki Theodorou, Melanie A Kimm, Mandy Boer, Lodewyk Wessels, Wendy Theelen, Jos Jonkers & John Hilkens

doi:10.1038/ng2034

Abstract - MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer | Full Text - MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer | PDF (284 KB) - MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer | Supplementary information

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes - pp770 - 775

Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Thorbjorg Jonsdottir, G Bragi Walters, Unnur Styrkarsdottir, Solveig Gretarsdottir, Valur Emilsson, Shyamali Ghosh, Adam Baker, Steinunn Snorradottir, Hjordis Bjarnason, Maggie C Y Ng, Torben Hansen, Yu Bagger, Robert L Wilensky, Muredach P Reilly, Adebowale Adeyemo, Yuanxiu Chen, Jie Zhou, Vilmundur Gudnason, Guanjie Chen, Hanxia Huang, Kerrie Lashley, Ayo Doumatey, Wing-Yee So, Ronald C Y Ma, Gitte Andersen, Knut Borch-Johnsen, Torben Jorgensen, Jana V van Vliet-Ostaptchouk, Marten H Hofker, Cisca Wijmenga, Claus Christiansen, Daniel J Rader, Charles Rotimi, Mark Gurney, Juliana C N Chan, Oluf Pedersen, Gunnar Sigurdsson, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong & Kari Stefansson

doi:10.1038/ng2043

First paragraph - A variant in : CDKAL1: influences insulin response and risk of type 2 diabetes | Full Text - A variant in CDKAL1 influences insulin response and risk of type 2 diabetes | PDF (1,441 KB) - A variant in CDKAL1 influences insulin response and risk of type 2 diabetes | Supplementary information

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion - pp776 - 780

Alice Bourdon, Limor Minai, Valérie Serre, Jean-Philippe Jais, Emmanuelle Sarzi, Sophie Aubert, Dominique Chrétien, Pascale de Lonlay, Véronique Paquis-Flucklinger, Hirofumi Arakawa, Yusuke Nakamura, Arnold Munnich & Agnès Rötig

doi:10.1038/ng2040

First paragraph - Mutation of : RRM2B: , encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion | Full Text - Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion | PDF (272 KB) - Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion | Supplementary information

See also: News and Views by Thelander

A conserved molecular pathway mediates myoblast fusion in insects and vertebrates - pp781 - 786

Bhylahalli P Srinivas, Jennifer Woo, Wan Ying Leong & Sudipto Roy

doi:10.1038/ng2055

First paragraph - A conserved molecular pathway mediates myoblast fusion in insects and vertebrates | Full Text - A conserved molecular pathway mediates myoblast fusion in insects and vertebrates | PDF (936 KB) - A conserved molecular pathway mediates myoblast fusion in insects and vertebrates | Supplementary information

See also: News and Views by Krauss

Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato - pp787 - 791

Naomi Ori, Aya Refael Cohen, Adi Etzioni, Arnon Brand, Osnat Yanai, Sharona Shleizer, Naama Menda, Ziva Amsellem, Idan Efroni, Irena Pekker, John Paul Alvarez, Eyal Blum, Dani Zamir & Yuval Eshed

doi:10.1038/ng2036

First paragraph - Regulation of : LANCEOLATE: by : miR319: is required for compound-leaf development in tomato | Full Text - Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato | PDF (664 KB) - Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato | Supplementary information

Root tip contact with low-phosphate media reprograms plant root architecture - pp792 - 796

Sergio Svistoonoff, Audrey Creff, Matthieu Reymond, Cécile Sigoillot-Claude, Lilian Ricaud, Aline Blanchet, Laurent Nussaume & Thierry Desnos

doi:10.1038/ng2041

First paragraph - Root tip contact with low-phosphate media reprograms plant root architecture | Full Text - Root tip contact with low-phosphate media reprograms plant root architecture | PDF (460 KB) - Root tip contact with low-phosphate media reprograms plant root architecture | Supplementary information

Spontaneous DNA breakage in single living Escherichia coli cells - pp797 - 802

Jeanine M Pennington & Susan M Rosenberg

doi:10.1038/ng2051

First paragraph - Spontaneous DNA breakage in single living : Escherichia coli: cells | Full Text - Spontaneous DNA breakage in single living Escherichia coli cells | PDF (322 KB) - Spontaneous DNA breakage in single living Escherichia coli cells | Supplementary information

See also: News and Views by Bielinsky

Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference - p803

Douglas A Rubinson, Christopher P Dillon, Adam V Kwiatkowski, Claudia Sievers, Lili Yang, Johnny Kopinja, Mingdi Zhang, Michael T McManus, Frank B Gertler, Martin L Scott & Luk Van Parijs

doi:10.1038/ng0607-803

Full Text - Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference | PDF (72 KB) - Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference