Brief Communication abstract
Nature Genetics 39, 724 - 726 (2007)
Published online: 13 May 2007 | Corrected online: 26 September 2007 | doi:10.1038/ng2048
There is a Corrigendum (October 2007) associated with this Brief Communication.
Variation in FTO contributes to childhood obesity and severe adult obesity
Christian Dina1, David Meyre1, Sophie Gallina1, Emmanuelle Durand1, Antje Körner2, Peter Jacobson3, Lena M S Carlsson3, Wieland Kiess2, Vincent Vatin1, Cecile Lecoeur1, Jérome Delplanque1, Emmanuel Vaillant1, François Pattou4, Juan Ruiz5, Jacques Weill6, Claire Levy-Marchal7, Fritz Horber8, Natascha Potoczna8, Serge Hercberg9, Catherine Le Stunff10, Pierre Bougnères10, Peter Kovacs11, Michel Marre12, Beverley Balkau13,14, Stéphane Cauchi1, Jean-Claude Chèvre1 & Philippe Froguel1,15
We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 
10-26 in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
- CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France.
- University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
- Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
- INSERM U859, Université de Lille 2, Lille, France.
- Diabétologie et Métabolisme, Centre Hospitalier Universitaire Vaudois (CHUV) BH19, Lausanne, Switzerland.
- Paediatric Endocrine Unit, Jeanne de Flandre Hospital, Lille, France.
- INSERM U690, Robert Debre Hospital, Paris, France.
- Klinik Lindberg, Winterthur, Switzerland.
- INSERM, U557, Bobigny, France; Institut Scientifique de Recherche Agronomique (INRA), U1125, Bobigny, France; Conservatoire National des Arts et Métiers (CNAM), EA3200, Paris, France; Paris 13 University, Bobigny, France; and Centre de Recherche en Nutrition Humaine (CRNH) Ile de France, Bobigny, France
- Department of Pediatric Endocrinology and INSERM U561, Saint Vincent de Paul Hospital, René Descartes University, Paris, France.
- Department of Internal Medicine III and Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany.
- Department of Diabetology, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
- INSERM U780-IFR69, Villejuif, France.
- Université Paris-Sud, Villejuif, France.
- Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK.
Correspondence to: Christian Dina1 e-mail: dina@good.ibl.fr
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Expert assessment of exposure to carcinogens in Norway's offshore petroleum industryJournal of Exposure Science and Environmental Epidemiology Article Response
Common nonsynonymous variants in PCSK1 confer risk of obesityNature Genetics Brief Communication (01 Aug 2008)
Common genetic variation near MC4R is associated with eating behaviour patterns in European populationsInternational Journal of Obesity Scientific Correspondence
No evidence of association between genetic variants of the PDCD1 ligands and SLEGenes and Immunity Original Article
See all 13 matches for Research
