Access

Letter

Nature Genetics 39, 678–682 (1 May 2007) | doi:10.1038/ng2029

Serotonin and neuropeptide F have opposite modulatory effects on fly aggression

Herman A Dierick & Ralph J Greenspan

Both serotonin (5-HT) and neuropeptide Y have been shown to affect a variety of mammalian behaviors, including aggression. Here we show in Drosophila melanogaster that both 5-HT and neuropeptide F, the invertebrate homolog of neuropeptide Y, modulate aggression.