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Letter

Nature Genetics 39, 645–649 (1 May 2007) | doi:10.1038/ng2022

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Meredith Yeager , Nick Orr , Richard B Hayes , Kevin B Jacobs , Peter Kraft , Sholom Wacholder , Mark J Minichiello , Paul Fearnhead , Kai Yu , Nilanjan Chatterjee , Zhaoming Wang , Robert Welch , Brian J Staats , Eugenia E Calle , Heather Spencer Feigelson , Michael J Thun , Carmen Rodriguez , Demetrius Albanes , Jarmo Virtamo , Stephanie Weinstein , Fredrick R Schumacher , Edward Giovannucci , Walter C Willett , Geraldine Cancel-Tassin , Olivier Cussenot , Antoine Valeri , Gerald L Andriole , Edward P Gelmann , Margaret Tucker , Daniela S Gerhard , Joseph F Fraumeni , Robert Hoover , David J Hunter , Stephen J Chanock & Gilles Thomas

Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility.