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Letter

Nature Genetics 39, 683–687 (1 May 2007) | doi:10.1038/ng2012

Genetic reconstruction of a functional transcriptional regulatory network

Zhanzhi Hu , Patrick J Killion & Vishwanath R Iyer

Although global analyses of transcription factor binding provide one view of potential transcriptional regulatory networks, regulation also occurs at levels distinct from transcription factor binding. Here, we use a genetic approach to identify targets of transcription factors in yeast and reconstruct a functional regulatory network.