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Nature Genetics 39, 631–637 (1 May 2007) | doi:10.1038/ng1999

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24

Julius Gudmundsson , Patrick Sulem , Andrei Manolescu , Laufey T Amundadottir , Daniel Gudbjartsson , Agnar Helgason , Thorunn Rafnar , Jon T Bergthorsson , Bjarni A Agnarsson , Adam Baker , Asgeir Sigurdsson , Kristrun R Benediktsdottir , Margret Jakobsdottir , Jianfeng Xu , Thorarinn Blondal , Jelena Kostic , Jielin Sun , Shyamali Ghosh , Simon N Stacey , Magali Mouy , Jona Saemundsdottir , Valgerdur M Backman , Kristleifur Kristjansson , Alejandro Tres , Alan W Partin , Marjo T Albers-Akkers , Javier Godino-Ivan Marcos , Patrick C Walsh , Dorine W Swinkels , Sebastian Navarrete , Sarah D Isaacs , Katja K Aben , Theresa Graif , John Cashy , Manuel Ruiz-Echarri , Kathleen E Wiley , Brian K Suarez , J Alfred Witjes , Mike Frigge , Carole Ober , Eirikur Jonsson , Gudmundur V Einarsson , Jose I Mayordomo , Lambertus A Kiemeney , William B Isaacs , William J Catalona , Rosa B Barkardottir , Jeffrey R Gulcher , Unnur Thorsteinsdottir , Augustine Kong & Kari Stefansson

Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%–13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans.