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Letter

Nature Genetics 39, 529–533 (1 April 2007) | doi:10.1038/2005

A functional polymorphism in the 5|[prime]| UTR of GDF5 is associated with susceptibility to osteoarthritis

Yoshinari Miyamoto , Akihiko Mabuchi , Dongquan Shi , Toshikazu Kubo , Yoshio Takatori , Susumu Saito , Mikihiro Fujioka , Akihiro Sudo , Atsumasa Uchida , Seizo Yamamoto , Koichi Ozaki , Masaharu Takigawa , Toshihiro Tanaka , Yusuke Nakamura , Qing Jiang & Shiro Ikegawa

Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide. Epidemiological and genetic studies have shown that osteoarthritis is a polygenic disease.