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Letter

Nature Genetics 39, 540–543 (1 April 2007) | doi:10.1038/ng1988

Mitochondrial point mutations do not limit the natural lifespan of mice

Marc Vermulst , Jason H Bielas , Gregory C Kujoth , Warren C Ladiges , Peter S Rabinovitch , Tomas A Prolla & Lawrence A Loeb

Whether mitochondrial mutations cause mammalian aging, or are merely correlated with it, is an area of intense debate. Here, we use a new, highly sensitive assay to redefine the relationship between mitochondrial mutations and age.