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Letter
Nature Genetics 39, 550–554 (1 April 2007) | doi:10.1038/ng1986
Epistatic buffering of fitness loss in yeast double deletion strains
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Abstract
Interactions between deleterious mutations have been insufficiently studied, despite the fact that their strength and direction are critical for understanding the evolution of genetic recombination and the buildup of mutational load in populations. We compiled a list of 758 yeast gene deletions causing growth defects (from the Munich Information Center for Protein Sequences database and ref.
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