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Nature Genetics 39, 443 - 445 (2007)
doi:10.1038/ng0407-443
Drosophila melanogaster neurofibromatosis-1: ROS, not Ras?
James A Walker1 & André Bernards1
- James A. Walker and André Bernards are at the Massachusetts General Hospital Center for Cancer Research, Boston, Massachusetts 02129, USA. e-mail: abernard@helix.mgh.harvard.edu
Abstract
A new study suggests that manipulating the expression of a Drosophila melanogaster neurofibromatosis-1 ortholog affects organismal lifespan through protein kinase A–mediated regulation of mitochondrial respiration and reactive oxygen species production. These results provide a new and unexpected twist to the study of NF1 signaling.
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RESEARCH
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogasterNature Genetics Article (01 Apr 2007)
