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Nature Genetics 39, 440 - 442 (2007)
doi:10.1038/ng0407-440
How missing genes interact
Clifford Zeyl1
- Clifford Zeyl is at the Department of Biology, Wake Forest University, Winston-Salem, North Carolina 27109, USA. e-mail: zeylcw@wfu.edu
Abstract
Epistasis is an interaction among genes that makes the phenotypic effect of an allele dependent on which alleles are present at other loci. Two new genomic studies find abundant epistasis in the yeast genome, with significant implications for the evolution of sex and for the inference of genetic pathways from genomic data.
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