News and Views
Nature Genetics 39, 439 - 440 (2007)
doi:10.1038/ng0407-439
The resequencing imperative
Eric J Topol1 & Kelly A Frazer1
- Eric J. Topol and Kelly A. Frazer are at Scripps Genomic Medicine, Scripps Health and The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. e-mail: etopol@scripps.edu or e-mail: kfrazer@scripps.edu
Abstract
The possibility of deep population resequencing of genes has generated excitement over its potentially promising role in understanding complex human traits. A new study has now demonstrated the utility of this approach, reporting the resequencing of a lipid metabolism gene in a large multiethnic population and definitively showing that coding variants in the gene are associated with plasma triglyceride levels.
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