Supplementary information : Protein tyrosine phosphatase 1B deficiency or inhibition delays : : ErbB2: : -induced mammary tumorigenesis and protects from lung metastasis : Nature Genetics

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Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

Sofi G Julien, Nadia Dubé, Michelle Read, Janice Penney, Marilene Paquet, Yongxin Han, Brian P Kennedy, William J Muller & Michel L Tremblay

Nature Genetics 39, 338 - 346 (2007)

doi:10.1038/ng1963

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Supplementary Fig. 1

PTP1B deficiency impairs tumorigenesis in NDL2 mice.

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Supplementary Fig. 2

Unaltered Src phosphorylation during mammary tumor progression in NDL2-ptpn1 null mice.

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Supplementary Fig. 3

Administration of PTP1B inhibitor in NDL2-ptpn1^+/+ normalizes glucose level.

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Supplementary Table 1

Summary of phenotypic abnormalities in MMTV-PTP1B transgenic mice.

Supplementary Table 1 - Download PDF file (60KB)

Supplementary Methods

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Supplementary Note

Supplementary Note - Download PDF file (100KB)

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Supplementary information