Supplementary information
From the following article
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
Jun Yamanouchi, Dan Rainbow, Pau Serra, Sarah Howlett, Kara Hunter, Valerie E S Garner, Andrea Gonzalez-Munoz, Jan Clark, Riitta Veijola, Rose Cubbon, Show-Ling Chen, Raymond Rosa, Anne Marie Cumiskey, David V Serreze, Simon Gregory, Jane Rogers, Paul A Lyons, Barry Healy, Luc J Smink, John A Todd, Laurence B Peterson, Linda S Wicker & Pere Santamaria
Nature Genetics 39, 329 - 337 (2007)
doi:10.1038/ng1958
Supplementary Fig. 1
The Idd3 region of mouse chromosome 3 and sequence coverage track and location of disease-associated SNPs in Il2 and Il21.
Supplementary Fig. 2
Correlation of disease susceptibility and resistance with Il2 expression in thymocytes.
Supplementary Fig. 3
Preferential production of IL-2 pre-mRNA from the resistant Il2 allele occurs in both CD4+ and CD8+ T cells and is a cis-regulated genetic event.
Supplementary Fig. 4
Phenotype and function of 8.3-CD8+ T cells in the presence or absence of the B6 Idd3 region.
Supplementary Fig. 5
5 IL-2 production competency as determined by intracellular IL-2 staining.
Supplementary Fig. 6
Enhanced development and function of CD4+ CD25+ Tregs in nontransgenic NOD.Idd3B6/B6 and B10.BR mice.
Supplementary Fig. 7
Phenotype and function of CD4+ CD25+ T cells from NOD and NOD.Idd3B6/B6 mice.
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