Nephrogenetics on World Kidney Day - p277

doi:10.1038/ng0307-277

Abstract - Nephrogenetics on World Kidney Day | Full Text - Nephrogenetics on World Kidney Day | PDF (84 KB) - Nephrogenetics on World Kidney Day

STOX1 is not imprinted and is not likely to be involved in preeclampsia - pp279 - 280

Isabel Iglesias-Platas, David Monk, Jiska Jebbink, Maarten Buimer, Kees Boer, Joris van der Post, Frank Hills, Sophia Apostolidou, Carrie Ris-Stalpers, Philip Stanier & Gudrun E Moore

doi:10.1038/ng0307-279

Full Text - STOX1 is not imprinted and is not likely to be involved in preeclampsia | PDF (187 KB) - STOX1 is not imprinted and is not likely to be involved in preeclampsia | Supplementary information

Reply to "STOX1 is not imprinted and is not likely to be involved in preeclampsia" - pp280 - 281

Marie van Dijk, Jan van Bezu, Stephen S Chim, Y M Dennis Lo, Marinus A Blankenstein & Cees B M Oudejans

doi:10.1038/ng0307-280

Full Text - Reply to "STOX1 is not imprinted and is not likely to be involved in preeclampsia" | PDF (88 KB) - Reply to "STOX1 is not imprinted and is not likely to be involved in preeclampsia" | Supplementary information

On the parsing of statistical information in family-based association testing - pp281 - 282

Matthew B McQueen, Scott Weiss, Nan M Laird & Christoph Lange

doi:10.1038/ng0307-281

Full Text - On the parsing of statistical information in family-based association testing | PDF (84 KB) - On the parsing of statistical information in family-based association testing

The devil is in the DNA - pp283 - 284

Stephen J Chanock & Gilles Thomas

doi:10.1038/ng0307-283

Full Text - The devil is in the DNA | PDF (377 KB) - The devil is in the DNA

See also: Letter by Thomas et al.

Enhancing genome annotation with chromatin - pp284 - 285

Dirk Schübeler

doi:10.1038/ng0307-284

Full Text - Enhancing genome annotation with chromatin | PDF (183 KB) - Enhancing genome annotation with chromatin

See also: Article by Heintzman et al.

Shaping specificity in signaling networks - pp286 - 287

Réka Albert & Zoltán N Oltvai

doi:10.1038/ng0307-286

Full Text - Shaping specificity in signaling networks | PDF (279 KB) - Shaping specificity in signaling networks

See also: Letter by McClean et al.

Think globally, act locally - pp287 - 289

Valerie Reinke

doi:10.1038/ng0307-287

Full Text - Think globally, act locally | PDF (237 KB) - Think globally, act locally

See also: Letter by Ercan et al.

DNMT1 knockout delivers a strong blow to genome stability and cell viability - pp289 - 290

Kevin D Brown & Keith D Robertson

doi:10.1038/ng0307-289

Full Text - DNMT1 knockout delivers a strong blow to genome stability and cell viability | PDF (130 KB) - DNMT1 knockout delivers a strong blow to genome stability and cell viability

See also: Letter by Chen et al.

Touching base - p291

doi:10.1038/ng0307-291

Full Text - Touching base | PDF (89 KB) - Touching base

Research highlights - p293

doi:10.1038/ng0307-293

Full Text - Research highlights | PDF (67 KB) - Research highlights

Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning - pp295 - 302

Xiangzhong Yang, Sadie L Smith, X Cindy Tian, Harris A Lewin, Jean-Paul Renard & Teruhiko Wakayama

doi:10.1038/ng1973

Abstract - Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning | Full Text - Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning | PDF (674 KB) - Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning

A genome-wide analysis in Saccharomyces cerevisiae demonstrates the influence of chromatin modifiers on transcription - pp303 - 309

Israel Steinfeld, Ron Shamir & Martin Kupiec

doi:10.1038/ng1965

Abstract - A genome-wide analysis in : Saccharomyces cerevisiae: demonstrates the influence of chromatin modifiers on transcription | Full Text - A genome-wide analysis in Saccharomyces cerevisiae demonstrates the influence of chromatin modifiers on transcription | PDF (673 KB) - A genome-wide analysis in Saccharomyces cerevisiae demonstrates the influence of chromatin modifiers on transcription | Supplementary information

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome - pp311 - 318

Nathaniel D Heintzman, Rhona K Stuart, Gary Hon, Yutao Fu, Christina W Ching, R David Hawkins, Leah O Barrera, Sara Van Calcar, Chunxu Qu, Keith A Ching, Wei Wang, Zhiping Weng, Roland D Green, Gregory E Crawford & Bing Ren

doi:10.1038/ng1966

Abstract - Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome | Full Text - Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome | PDF (688 KB) - Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome | Supplementary information

See also: News and Views by Schübeler

Mapping autism risk loci using genetic linkage and chromosomal rearrangements - pp319 - 328

The Autism Genome Project Consortium

doi:10.1038/ng1985

Abstract - Mapping autism risk loci using genetic linkage and chromosomal rearrangements | Full Text - Mapping autism risk loci using genetic linkage and chromosomal rearrangements | PDF (876 KB) - Mapping autism risk loci using genetic linkage and chromosomal rearrangements | Supplementary information

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity - pp329 - 337

Jun Yamanouchi, Dan Rainbow, Pau Serra, Sarah Howlett, Kara Hunter, Valerie E S Garner, Andrea Gonzalez-Munoz, Jan Clark, Riitta Veijola, Rose Cubbon, Show-Ling Chen, Raymond Rosa, Anne Marie Cumiskey, David V Serreze, Simon Gregory, Jane Rogers, Paul A Lyons, Barry Healy, Luc J Smink, John A Todd, Laurence B Peterson, Linda S Wicker & Pere Santamaria

doi:10.1038/ng1958

Abstract - Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity | Full Text - Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity | PDF (447 KB) - Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity | Supplementary information

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis - pp338 - 346

Sofi G Julien, Nadia Dubé, Michelle Read, Janice Penney, Marilene Paquet, Yongxin Han, Brian P Kennedy, William J Muller & Michel L Tremblay

doi:10.1038/ng1963

Abstract - Protein tyrosine phosphatase 1B deficiency or inhibition delays : : ErbB2: : -induced mammary tumorigenesis and protects from lung metastasis | Full Text - Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis | PDF (528 KB) - Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis | Supplementary information

High-throughput oncogene mutation profiling in human cancer - pp347 - 351

Roman K Thomas, Alissa C Baker, Ralph M DeBiasi, Wendy Winckler, Thomas LaFramboise, William M Lin, Meng Wang, Whei Feng, Thomas Zander, Laura E MacConaill, Jeffrey C Lee, Rick Nicoletti, Charlie Hatton, Mary Goyette, Luc Girard, Kuntal Majmudar, Liuda Ziaugra, Kwok-Kin Wong, Stacey Gabriel, Rameen Beroukhim, Michael Peyton, Jordi Barretina, Amit Dutt, Caroline Emery, Heidi Greulich, Kinjal Shah, Hidefumi Sasaki, Adi Gazdar, John Minna, Scott A Armstrong, Ingo K Mellinghoff, F Stephen Hodi, Glenn Dranoff, Paul S Mischel, Tim F Cloughesy, Stan F Nelson, Linda M Liau, Kirsten Mertz, Mark A Rubin, Holger Moch, Massimo Loda, William Catalona, Jonathan Fletcher, Sabina Signoretti, Frederic Kaye, Kenneth C Anderson, George D Demetri, Reinhard Dummer, Stephan Wagner, Meenhard Herlyn, William R Sellers, Matthew Meyerson & Levi A Garraway

doi:10.1038/ng1975

First paragraph - High-throughput oncogene mutation profiling in human cancer | Full Text - High-throughput oncogene mutation profiling in human cancer | PDF (414 KB) - High-throughput oncogene mutation profiling in human cancer | Supplementary information

See also: News and Views by Chanock & Thomas

A common coding variant in CASP8 is associated with breast cancer risk - pp352 - 358

Angela Cox, Alison M Dunning, Montserrat Garcia-Closas, Sabapathy Balasubramanian, Malcolm W R Reed, Karen A Pooley, Serena Scollen, Caroline Baynes, Bruce A J Ponder, Stephen Chanock, Jolanta Lissowska, Louise Brinton, Beata Peplonska, Melissa C Southey, John L Hopper, Margaret R E McCredie, Graham G Giles, Olivia Fletcher, Nichola Johnson, Isabel dos Santos Silva, Lorna Gibson, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Diana Torres, Ute Hamann, Christina Justenhoven, Hiltrud Brauch, Jenny Chang-Claude, Silke Kropp, Angela Risch, Shan Wang-Gohrke, Peter Schürmann, Natalia Bogdanova, Thilo Dörk, Rainer Fagerholm, Kirsimari Aaltonen, Carl Blomqvist, Heli Nevanlinna, Sheila Seal, Anthony Renwick, Michael R Stratton, Nazneen Rahman, Suleeporn Sangrajrang, David Hughes, Fabrice Odefrey, Paul Brennan, Amanda B Spurdle, Georgia Chenevix-Trench, The Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer, Jonathan Beesley, Arto Mannermaa, Jaana Hartikainen, Vesa Kataja, Veli-Matti Kosma, Fergus J Couch, Janet E Olson, Ellen L Goode, Annegien Broeks, Marjanka K Schmidt, Frans B L Hogervorst, Laura J Van't Veer, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Sara Wedrén, Per Hall, Yen-Ling Low, Jianjun Liu, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, Alice J Sigurdson, Denise L Stredrick, Bruce H Alexander, Jeffery P Struewing, Paul D P Pharoah & Douglas F Easton, on behalf of the Breast Cancer Association Consortium

doi:10.1038/ng1981

First paragraph - A common coding variant in : : CASP8: : is associated with breast cancer risk | Full Text - A common coding variant in CASP8 is associated with breast cancer risk | PDF (318 KB) - A common coding variant in CASP8 is associated with breast cancer risk | Supplementary information

Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta - pp359 - 365

Wayne A Cabral, Weizhong Chang, Aileen M Barnes, MaryAnn Weis, Melissa A Scott, Sergey Leikin, Elena Makareeva, Natalia V Kuznetsova, Kenneth N Rosenbaum, Cynthia J Tifft, Dorothy I Bulas, Chahira Kozma, Peter A Smith, David R Eyre & Joan C Marini

doi:10.1038/ng1968

First paragraph - Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta | Full Text - Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta | PDF (375 KB) - Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta | Supplementary information

Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum - pp366 - 372

Giovanni Stevanin, Filippo M Santorelli, Hamid Azzedine, Paula Coutinho, Jacques Chomilier, Paola S Denora, Elodie Martin, Anne-Marie Ouvrard-Hernandez, Alessandra Tessa, Naïma Bouslam, Alexander Lossos, Perrine Charles, José L Loureiro, Nizar Elleuch, Christian Confavreux, Vítor T Cruz, Merle Ruberg, Eric Leguern, Djamel Grid, Meriem Tazir, Bertrand Fontaine, Alessandro Filla, Enrico Bertini, Alexandra Durr & Alexis Brice

doi:10.1038/ng1980

First paragraph - Mutations in : : SPG11: : , encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum | Full Text - Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum | PDF (394 KB) - Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum | Supplementary information

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes - pp373 - 379

Aaron B Bowman, Yung C Lam, Paymaan Jafar-Nejad, Hung-Kai Chen, Ronald Richman, Rodney C Samaco, John D Fryer, Juliette J Kahle, Harry T Orr & Huda Y Zoghbi

doi:10.1038/ng1977

First paragraph - Duplication of : Atxn1l: suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes | Full Text - Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes | PDF (414 KB) - Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes | Supplementary information

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal - pp380 - 385

Yangming Wang, Rostislav Medvid, Collin Melton, Rudolf Jaenisch & Robert Blelloch

doi:10.1038/ng1969

First paragraph - : DGCR8: : is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal | Full Text - DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal | PDF (370 KB) - DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal | Supplementary information

The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells - pp386 - 390

Liqin Cao, Hiroshi Shitara, Takuro Horii, Yasumitsu Nagao, Hiroshi Imai, Kuniya Abe, Takahiko Hara, Jun-Ichi Hayashi & Hiromichi Yonekawa

doi:10.1038/ng1970

First paragraph - The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells | Full Text - The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells | PDF (191 KB) - The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells | Supplementary information

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells - pp391 - 396

Taiping Chen, Sarah Hevi, Frédérique Gay, Naomi Tsujimoto, Timothy He, Bailin Zhang, Yoshihide Ueda & En Li

doi:10.1038/ng1982

First paragraph - Complete inactivation of : : DNMT1: : leads to mitotic catastrophe in human cancer cells | Full Text - Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells | PDF (403 KB) - Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells | Supplementary information

See also: News and Views by Brown & Robertson

Fgf10 regulates hepatopancreatic ductal system patterning and differentiation - pp397 - 402

P Duc Si Dong, Chantilly A Munson, William Norton, Cecile Crosnier, Xiufang Pan, Zhiyuan Gong, Carl J Neumann & Didier Y R Stainier

doi:10.1038/ng1961

First paragraph - : Fgf10: : regulates hepatopancreatic ductal system patterning and differentiation | Full Text - Fgf10 regulates hepatopancreatic ductal system patterning and differentiation | PDF (524 KB) - Fgf10 regulates hepatopancreatic ductal system patterning and differentiation | Supplementary information

X chromosome repression by localization of the C. elegans dosage compensation machinery to sites of transcription initiation - pp403 - 408

Sevinc Ercan, Paul G Giresi, Christina M Whittle, Xinmin Zhang, Roland D Green & Jason D Lieb

doi:10.1038/ng1983

First paragraph - X chromosome repression by localization of the : C. elegans: dosage compensation machinery to sites of transcription initiation | Full Text - X chromosome repression by localization of the C. elegans dosage compensation machinery to sites of transcription initiation | PDF (716 KB) - X chromosome repression by localization of the C. elegans dosage compensation machinery to sites of transcription initiation | Supplementary information

See also: News and Views by Reinke

Cross-talk and decision making in MAP kinase pathways - pp409 - 414

Megan N McClean, Areez Mody, James R Broach & Sharad Ramanathan

doi:10.1038/ng1957

First paragraph - Cross-talk and decision making in : : MAP: : kinase pathways | Full Text - Cross-talk and decision making in MAP kinase pathways | PDF (388 KB) - Cross-talk and decision making in MAP kinase pathways | Supplementary information

See also: News and Views by Albert & Oltvai

Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species - pp415 - 421

Orna Man & Yitzhak Pilpel

doi:10.1038/ng1967

First paragraph - Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species | Full Text - Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species | PDF (273 KB) - Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species | Supplementary information

CORRIGENDUM: Genome variation and evolution of the malaria parasite Plasmodium falciparum - p422

Daniel C Jeffares, Arnab Pain, Andrew Berry, Anthony V Cox, James Stalker, Catherine E Ingle, Alan Thomas, Michael A Quail, Kyle Siebenthall, Anne-Catrin Uhlemann, Sue Kyes, Sanjeev Krishna, Chris Newbold, Emmanouil T Dermitzakis & Matthew Berriman

doi:10.1038/ng0307-422

Full Text - CORRIGENDUM: Genome variation and evolution of the malaria parasite Plasmodium falciparum | PDF (50 KB) - CORRIGENDUM: Genome variation and evolution of the malaria parasite Plasmodium falciparum