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Micromanaging the response to Hedgehog

Members of the Hedgehog family of secreted proteins are central to animal development, with different levels of Hedgehog signaling activity specifying distinct cellular identities. A new study shows that a microRNA is involved in this process by modulating a component of the Hedgehog signal transduction pathway.

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Figure 1: Shh protein secreted by the notochord signals cells in the adjacent somite of the zebrafish embryo.

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Ingham, P. Micromanaging the response to Hedgehog. Nat Genet 39, 145–146 (2007). https://doi.org/10.1038/ng0207-145

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