Members of the Hedgehog family of secreted proteins are central to animal development, with different levels of Hedgehog signaling activity specifying distinct cellular identities. A new study shows that a microRNA is involved in this process by modulating a component of the Hedgehog signal transduction pathway.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hammond, S.M. FEBS Lett. 579, 5822–5829 (2005).
Valencia-Sanchez, M.A., Liu, J., Hannon, G.J. & Parker, R. Genes Dev. 20, 515–524 (2006).
Kloosterman, W.P. & Plasterk, R.H. Dev. Cell 11, 441–450 (2006).
Flynt, A.S., Li, N., Thatcher, E.J., Solnica-Krezel, L. & Patton, J.G. Nat. Genet. 39, 259–263 (2007).
Ingham, P.W. & Placzek, M. Nat. Rev. Genet. 7, 841–850 (2006).
Giraldez, A.J. et al. Science 308, 833–838 (2005).
Giraldez, A.J. et al. Science 312, 75–79 (2006).
Wolff, C., Roy, S. & Ingham, P.W. Curr. Biol. 13, 1169–1181 (2003).
Ingham, P.W. & McMahon, A.P. Genes Dev. 15, 3059–3087 (2001).
Cooper, A.F. et al. Development 132, 4407–4417 (2005).
Svard, J. et al. Dev. Cell 10, 187–197 (2006).
Koudijs, M.J. et al. PLoS Genet. 1, e19 (2005)
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Ingham, P. Micromanaging the response to Hedgehog. Nat Genet 39, 145–146 (2007). https://doi.org/10.1038/ng0207-145
Issue Date:
DOI: https://doi.org/10.1038/ng0207-145