News and Views
Nature Genetics 39, 142 - 143 (2007)
doi:10.1038/ng0207-142
Fanconi anemia and breast cancer susceptibility
Ketan J Patel1
- Ketan J. Patel is at the Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK. e-mail: kjp@mrc-lmb.cam.ac.uk
Abstract
Two new studies show that the Fanconi anemia complementation group N results from biallelic mutations in PALB2, which encodes a recently identified interaction partner of the breast cancer susceptibility protein BRCA2. A third study shows that monoallelic PALB2 mutations are associated with breast cancer susceptibility, providing yet more links between Fanconi anemia, homologous recombination repair and cancer predisposition.
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